How prodrugs can target cancer cells specifically?

Currently there aren’t any remedies to target cancer cells selectively. Most drugs that exterminate rapidly proliferating cancer cells can also eradicate normal healthy cells. Even monoclonal antibodies (mAbs), present best treatment modalities in the targeted cancer immunotherapy, fail to destroy cancer cells specifically and a lot of mechanism-dependent or independent toxicities have been reported. Targeting tumor cells specifically needs necessary strategies to progress the cancer therapies. Advanced researches in cancer biology have been illustrated that cancer cells have usually some genes that are overor under-expressed. To exterminate tumor cells specifically, the current effort puts forward a novel strategy to target cancer cells more selectively using Enzyme Activated Prodrugs (EAP), which can be activated by over-expressed enzymes of cancer cells. Mutations in genes and chromosomes are known triggers for the development of human cancers. The mutations in gene profile could overor under-express several enzymes which can be used in cancer targeting by EAP.